Spectrophotometric Determination of Pharmaceutical by Oxidative Coupling of 4-Aminoantipyrine: A Short Review

Spectrophotometric determination of ritodrine and isoxsuprine hydrochlorides using 4-aminoantipyrine.

A simple, accurate, and rapid method for the quantitative determination of ritodrine hydrochloride (RTH) and isoxsuprine hydrochloride (ISH) in both pure and dosage forms, is described. The method is based on the development of pink colored product as a result of the condensation of 4-aminoantipyrine with phenols in the presence of an alkaline oxidizing agent. The resulting products are measure...

Flow injection spectrophotometric determination of amoxicillin in pharmaceutical samples by coupling with diazotized p- nitroaniline

A spectrophotometric method using flow injection analysis (FIA) is described for the determination of amoxicillin (AMX). Its detection limit, linearity and reproducibility were examined.The automated method is based on a coupling reaction between AMX and diazotized paranitroaniline (DPNA) in alkaline medium to form an intense reddishorange, water-soluble dye that is stable and has a maximum abs...

Spectrophotometric Determination of Corticosteroids and Its Application in Pharmaceutical Formulation

A simple, sensitive and economically viable spectrophotometric method for the determination of corticosteroids (predinsolone {PSL}, dexamethasone {DEX}, prednisone {PS}, betamethasone sodium phosphate {BEP} and hydrocortisone {HYD} has been developed. The method involves the oxidation of corticosteroids by iron (III) and subsequent complexation of iron (II) with potassium hexacynoferrate (III),...

Spectrophotometric Determination of Cephalosporins in Pharmaceutical Samples

Spectrophotometric Determination of Metronidazole in Pharmaceutical Preparations

A rapid and sensitive spectrophotometric method is proposed for determination of Metronidazole. The method depends on the reduction of Metronidazole molecule with zinc dust and hydrochloric acid flowed by diazotation and coupling with 8-quinolinol to give colored chromogens easily measured spectrophotometrically which has λmax= 437 nm. The experimental conditions were optimized and berr’s law w...